{"id":144777,"date":"2019-06-03T17:37:48","date_gmt":"2019-06-03T15:37:48","guid":{"rendered":"http:\/\/www.arabtelegraph.com\/?p=144777"},"modified":"2019-06-03T17:39:39","modified_gmt":"2019-06-03T15:39:39","slug":"rogue-chinese-scientist-made-foolish-choice-in-gene-edited-babies","status":"publish","type":"post","link":"https:\/\/www.arabtelegraph.com\/?p=144777","title":{"rendered":"Rogue Chinese scientist made &#8220;foolish&#8221; choice in gene-edited babies"},"content":{"rendered":"<figure id=\"attachment_144780\" aria-describedby=\"caption-attachment-144780\" style=\"width: 385px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.arabtelegraph.com\/wp-content\/uploads\/2019\/06\/Scientist-He-Jiankui-speaks-during-the-International-Summit-on-Human-Genome-Editing-at-the-University-of-Hong-Kong-in-Hong-Kong-China.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\" wp-image-144780\" src=\"https:\/\/www.arabtelegraph.com\/wp-content\/uploads\/2019\/06\/Scientist-He-Jiankui-speaks-during-the-International-Summit-on-Human-Genome-Editing-at-the-University-of-Hong-Kong-in-Hong-Kong-China-300x169.jpg\" alt=\"Scientist He Jiankui speaks during the International Summit on Human Genome Editing at the University of Hong Kong in Hong Kong, China\" width=\"385\" height=\"217\" srcset=\"https:\/\/www.arabtelegraph.com\/wp-content\/uploads\/2019\/06\/Scientist-He-Jiankui-speaks-during-the-International-Summit-on-Human-Genome-Editing-at-the-University-of-Hong-Kong-in-Hong-Kong-China-300x169.jpg 300w, https:\/\/www.arabtelegraph.com\/wp-content\/uploads\/2019\/06\/Scientist-He-Jiankui-speaks-during-the-International-Summit-on-Human-Genome-Editing-at-the-University-of-Hong-Kong-in-Hong-Kong-China.jpg 660w\" sizes=\"(max-width: 385px) 100vw, 385px\" \/><\/a><figcaption id=\"caption-attachment-144780\" class=\"wp-caption-text\">Scientist He Jiankui speaks during the International Summit on Human Genome Editing at the University of Hong Kong in Hong Kong, China<\/figcaption><\/figure>\n<p dir=\"ltr\"><strong>A rogue Chinese scientist who caused outrage last year when he said he had created the world\u2019s first \u201cgene-edited\u201d babies in an attempt to protect them from HIV may also have put them at risk with a \u201cfoolish\u201d choice of gene, experts said on Monday.<\/strong><br \/>\nHe Jiankui, then an associate professor at the Southern University of Science and Technology in Shenzhen, China, sparked an international scientific and ethical row when he said he had used a technology known as CRISPR-Cas9 to alter the embryonic genes of twin girls born in November 2018.<\/p>\n<p dir=\"ltr\">He said he had targeted a gene known as CCR5 and edited it in a way he believed would protect the girls from infection with HIV, the virus that causes AIDS.<\/p>\n<p dir=\"ltr\">But in a study published in the journal Nature Medicine on Monday, scientists found that people who have two copies of a so-called \u201cDelta 32\u201d mutation of CCR5 &#8211; which protects against HIV infection in some people &#8211; also have a significantly higher risk of premature death.<\/p>\n<p dir=\"ltr\">The researchers, Xinzhu Wei and Rasmus Nielsen of the University of California, Berkeley, said their findings showed the unintended consequences of introducing mutations in humans.<\/p>\n<p dir=\"ltr\">Robin Lovell-Badge, a leading geneticist and the organiser of a conference where He Jiankui made his revelation, said the results showed the Chinese scientist \u201cwas foolish to choose CCR5 to mutate in his attempts at germline genome editing\u201d.<\/p>\n<p dir=\"ltr\">\u201cWe simply do not yet know enough about the gene,\u201d said Lovell-Badge, a professor and gene expert at Britain\u2019s Francis Crick Institute.<\/p>\n<p dir=\"ltr\">He Jiankui could not immediately be reached for comment.<\/p>\n<p dir=\"ltr\">Other specialists agreed the findings underline a need for extreme caution when considering possible human applications of gene editing technologies.<\/p>\n<p dir=\"ltr\">\u201cThis study should act as a stark warning that manipulation of the human genome with the aim of reducing susceptibility to specific diseases is not without considerable risk,\u201d said Andrew Freedman, an infectious diseases expert at Cardiff University.<\/p>\n<p dir=\"ltr\">The Berkeley team\u2019s study analysed genotype and death register details from more than 400,000 people registered at the UK Biobank &#8211; an database of health and genetic information.<\/p>\n<p dir=\"ltr\">They found that people who have two copies of the Delta 32 mutation are about 20% less likely to reach age 76 compared with people who have one or no copies.<\/p>\n<p dir=\"ltr\">Chinese authorities immediately denounced He when he made his claim last year, and issued a temporary halt to research activities involving the editing of human genes. He was fired after a subsequent Chinese health commission investigation found he had \u201cdeliberately evaded oversight\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A rogue Chinese scientist who caused outrage last year when he said he had created the world\u2019s first \u201cgene-edited\u201d babies in an attempt to protect them from HIV may also have put them at risk with a \u201cfoolish\u201d choice of gene, experts said on Monday. He Jiankui, then an associate professor at the Southern University &hellip;<\/p>\n","protected":false},"author":3,"featured_media":144778,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-144777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-te-public"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rogue Chinese scientist made &quot;foolish&quot; choice in gene-edited babies - Arab Telegraph<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.arabtelegraph.com\/?p=144777\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rogue Chinese scientist made &quot;foolish&quot; choice in gene-edited babies - Arab Telegraph\" \/>\n<meta property=\"og:description\" content=\"A rogue Chinese scientist who caused outrage last year when he said he had created the world\u2019s first \u201cgene-edited\u201d babies in an attempt to protect them from HIV may also have put them at risk with a \u201cfoolish\u201d choice of gene, experts said on Monday. 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